Jujuboside

The seed of Ziziphus jujube Mill. var. spinosa (Bunge) Hu ex H. F. Chou, Suanzaoren in Chinese, is one of commonly used Chinese medicines. Saponins and fatty oil contains several fatty acids in Suanzaoren are responsible for its therapeutic activities. This herb has ujuboside A, jujuboside B, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, arachidic acid and docosanoic acid.

Health benefit of jujuboside
Jujuboside A is a main component of jujubogenin extracted from the seed of Ziziphus jujuba Mill var spinosa (Bunge) Hu ex H F Chou (Ziziphus), which is widely used in Chinese traditional medicine for the treatment of insomnia and anxiety.

Upregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus.
Acta Pharmacol Sin. 2007 March. School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.
To investigate the effect of jujuboside A on modulating gene expression in the hippocampus. The spontaneous activity of mice was monitored, and the differential display polymerase chain reaction was adapted to screen differentially-expressed genes modulated by JuA in the mouse hippocampus. Jujuboside significantly decreased the total activity intensity (P<0.01 vs control) at a dosage of 80 mg/kg, and the genes MAP/microtubule affinity-regulating kinase3 (Mark3) and retinitis pigmentosa GTPase regulator interacting protein1 (Rpgrip1) were upregulated by JuA in the mouse hippocampus.  jujuboside had an inhibitory effect on the spontaneous activity of the mice, and jujuboside regulated the transcription of Mark3 and Rpgrip1 in the mouse hippocampus.

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